The combination of PTS and aspirin could reduce adverse gastrointestinal effects by regulating the TXA 2/PGI 2 ratio. ResultsĬompared with PNS, PTS showed a stronger and more potent anti-platelet aggregation effect in MCAO model rats. To evaluate therapeutic effects and explore possible mechanisms of anti-platelet aggregation, we measured cerebral infarct size and water content in brain tissue, histomorphological changes, expression of related factors (such as arachidonic acid metabolites) and platelet receptors in serum, as well as the binding affinity of PTS for platelet adhesion receptors. Panax notoginseng total saponins (PNS) and a combination of PTS and aspirin were chosen for comparison. Three oral doses of PTS were administered in a model of middle cerebral artery occlusion (MCAO) in rats. In this study, anti-platelet aggregation-related protein analysis and computer simulations of drug-protein binding interactions were performed to explore the mechanism of the effects of PTS against ischemic stroke in an ischemia reperfusion model. Panax notoginseng triol saponins (PTS) has been used clinically for ischemic stroke therapy (IST) in China for more than 17 years due to its anti-platelet aggregation and neuro-protective effects, but its mechanism of action is not fully understand.
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